Research Paper Volume 12, Issue 24 pp 25120—25137

Apelin protects against ischemia-reperfusion injury in diabetic myocardium via inhibiting apoptosis and oxidative stress through PI3K and p38-MAPK signaling pathways

Figure 4. Role of Apelin on cardiac infarction and pathology in cardiac IRI rats. (A, B). The infarction of cardiac was evaluated by TTC staining. ***P<0.001 versus D-IRI. (C) The pathology of myocardium was assessed by HE staining. Magnification, ×200. TTC: triphenyltetrazoliu chloride; HE: Hematoxylin-eosin; D-Sham: Diabetes sham group; D-IRI: Diabetes ischemia reperfusion injury; Ad-GFP: D-IRI rats injected with Ad-recombined lentiviral vector expressing GFP. Ad-Apelin: D-IRI rats injected with Ad-recombined lentiviral rector expressing Apelin.