Figure 1. Changes in the autophagy and inflammation observed in ovaries from young and old mice. (A) Western blot analysis with representative blot of IL-6 levels in cardiac tissue of 3 and 20-mo-old WT and Nlrp3 -/-. (B) Western blot analysis showing the protein expression of inflammatory markers IL-6 in cardiac tissues of old mice after MCC950 treatment. n= 4 mice per group and age. Densitometric analysis is shown as means ± SD. ***P < 0.001, **P < 0.01, young vs old mice.