Figure 5. SETD2 suppressed cell cycle progression. (A) GO and (B) KEGG analysis showed the altered pathways in the absence of SETD2. (C) Gene co-interaction network identified crucial roles of CTNNB1, WNT3 and RAC1 in lung cancer which were marked by asterisks. Green lines represented the negative regulation between two genes, and red lines represented positive regulation. (D) Protein levels of G1 phase checkpoints Cyclin D1 and Cyclin E1 upon SETD2 overexpression or knockdown in H1650 and PC-9 cells. Quantitative results were shown on the right. *P<0.05. Two-tailed Student’s t test.