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Research Paper Volume 12, Issue 24 pp 25229—25255

Exposure to ozone impacted Th1/Th2 imbalance of CD4+ T cells and apoptosis of ASMCs underlying asthmatic progression by activating lncRNA PVT1-miR-15a-5p/miR-29c-3p signaling

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Figure 9. The mechanism diagram about impacts of lncRNA PVT1–centered miRNA networks and ozone on asthmatic progression. It was revealed that exposure to ozone impacted Th1/Th2 imbalance of CD4+ T cells by regulating lncRNA PVT1-miR-15a-5p-PI3K/AKT/mTOR axis and apoptosis of ASMCs through modifying lncRNA PVT1-miR-29c-3p- PI3K/AKT/mTOR axis.