Research Paper Volume 12, Issue 24 pp 25452—25468

Sevoflurane postconditioning reduces myocardial ischemia reperfusion injury-induced necroptosis by up-regulation of OGT-mediated O-GlcNAcylated RIPK3

Figure 1. SPC reduced myocardial infarction size, recovered cardiac function, decreased LDH level and attenuated histopathological changes. (A) Myocardial infarct size was measured by 1% TTC and expressed as a percentage of area at risk. n=6/group. (B) Myocardial necroptosis marker enzyme LDH was determined by commercially available LDH kits. n=6/group. (C) Representative M-mode images of echocardiography and EF%, FS% were recorded in all groups. n=8/group. (D) Representative H&E staining images are shown (magnification, 400×). Scale bar, 50μm. n = 3/group. The columns and errors bars represent means ± SD. * P < 0.05 vs. SHAM group; # P < 0.05 vs. IR group.