Research Paper Volume 12, Issue 24 pp 25487—25504

Pentoxifylline enhances antioxidative capability and promotes mitochondrial biogenesis for improving age-related behavioral deficits


Figure 8. Effects of PTX treatment on mitochondrial biogenesis in the HIPP in aged rats. (AC) PGC-1α, NRF-1, and TFAM mRNA levels were detected by qPCR. (DF) Representative Western blots of PGC-1α, NRF-1, and TFAM protein levels. (GI) PGC-1α, NRF-1, and TFAM protein levels were quantified relative to β-actin band density. Data are expressed as the mean ± S.D. (n=6 rats/group). *P<0.05, **P<0.01.