Research Paper Volume 12, Issue 24 pp 25505—25527

Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway

Figure 8. Sesn2 serves as antioxidants by improving P62-dependent autophagic degradation of Keap1 and thereby promoting Nrf2 expression and activity. When Sesn2 binds to P62 and Keap1, P62 binds to LC3 simultaneously at autophagosomes and thereby promote Keap1 degradation. The degradation of Keap1 was found to have led to Nrf2 expression and activation, and then promoted the transcription of genes for various antioxidant enzymes.