Research Paper Volume 12, Issue 24 pp 25564—25580

TRIM27 acts as an oncogene and regulates cell proliferation and metastasis in non-small cell lung cancer through SIX3-β-catenin signaling

Figure 3. SIX3 regulates NSCLC cell proliferation, invasion, and migration. H1975 cells were transfected with siSIX3-1, siSIX3-2, or siNC, and cell proliferation (A), migration (B), and invasion (C) were determined by CCK-8 and transwell assay. A549 cells were infected with pLVX-Puro-SIX3 or blank pLVX-Puro vector, and cell proliferation (D), migration (E), and invasion (F) were determined by CCK-8 and transwell assay. All experiments were repeated at least three times, and data are represented as mean ± SD. ***P < 0.001 (two-way ANOVA followed by Dunnett’s test).