Research Paper Volume 12, Issue 24 pp 25564—25580

TRIM27 acts as an oncogene and regulates cell proliferation and metastasis in non-small cell lung cancer through SIX3-β-catenin signaling

Figure 4. SIX3 overexpression inhibits NSCLC cell proliferation, migration, and invasion induced by TRIM27 overexpression. H1975 cells were infected with blank pLVX-Puro vector, pLVX-Puro-TRIM27, or pLVX-Puro-SIX3, and cell proliferation (A), migration (B), invasion (C), and related protein expression (D, E) were determined by CCK-8, transwell assay, and western blot analysis. All experiments were repeated at least three times, and data are represented as mean ± SD. ***P < 0.001 (two-way ANOVA followed by Dunnett’s test).