Research Paper Volume 12, Issue 24 pp 25564—25580

TRIM27 acts as an oncogene and regulates cell proliferation and metastasis in non-small cell lung cancer through SIX3-β-catenin signaling

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Figure 5.

The roles of TRIM27 and SIX3 on lung metastasis in vivo. (A) Histology of single lung lobe from mice intravenously injected with A549 cells stably infected with blank pLVX-Puro vector, pLVX-Puro-TRIM27, or pLVX-Puro-SIX3. Scale bars: 500 μm. (B) Quantification of microscopic nodules in the lungs of each group. (C) The incidence of metastasis in mice after intravenous tail injection of each cell type is shown in the table. All experiments were repeated at least three times, and data are represented as mean ± SD. *P < 0.05, ***P < 0.001 (two-way ANOVA followed by Dunnett’s test).