Research Paper Volume 12, Issue 24 pp 25564—25580

TRIM27 acts as an oncogene and regulates cell proliferation and metastasis in non-small cell lung cancer through SIX3-β-catenin signaling

Figure 6. TRIM27 and SIX3 regulate NSCLC cell migration and invasion partly through the Wnt/β-catenin pathway. H1975 cells transfected or infected with siSIX3-1, pLVX-Puro-TRIM27, or both siNC and blank pLVX-Puro vector were treated with DMSO or 10 μM XAV939, and cell migration, invasion, and related protein expression were determined by transwell assay (AC) and western blotting (D). All experiments were repeated at least three times, and data are represented as mean ± SD. ***P < 0.001 (two-way ANOVA followed by Dunnett’s test).