Research Paper Volume 12, Issue 24 pp 25643—25657

Neurofilament degradation is involved in laparotomy-induced cognitive dysfunction in aged rats

Figure 1. TSA can mitigate surgery-induced spatial learning and memory impairments in aged rats. (A, B) Acquisition trials demonstrating latencies for rats to locate the hidden platform during the 5 testing days (A) and the swimming speed (B), measuring spatial information acquisition. (C, D) On test day 6, probe trials demonstrating the time to first platform crossing (C) and time spent in the target quadrant (D), measuring memory retention capabilities. (E) Representative searching swimming paths of four aged rats with different treatments in the probe trial tests. Data are given as means {plus minus} SEM, n = 12. *P < 0.05 vs. the control group; #P < 0.05 vs. the surgery group.