Research Paper Volume 12, Issue 24 pp 25643—25657

Neurofilament degradation is involved in laparotomy-induced cognitive dysfunction in aged rats

Figure 3. Effects of laparotomy on the levels of hippocampal IL-1β and TNF-α in aged rats. Compared with control rats, significant changes in the levels of IL-1β (A) and TNF-α (B) are observed at 6 h, 24 h and 72 h after surgery, which was significantly inhibited by TSA pretreatment. Data are given as means {plus minus} SEM, n = 5. ***P < 0.001 vs. the control group; #P < 0.05 vs. the surgery group.