Research Paper Volume 13, Issue 3 pp 3342—3352

The DNA methylation-regulated MCTP1 activates the drug-resistance of esophageal cancer cells

The effects of the forced reversal of MCTP1 levels on the activity of the signaling pathways in Kyse450 versus Kyse510 cells. (A) The activity of the seventeen pathways in Kyse450 versus Kyse510 cells, and there is great difference among TGFβ, NFκB, MAPK/JNK cAMP/PKA, Hypoxia and IL-6 pathways. (B) The relative pathway activities of the three different regions’ si-MCTP1 versus the negative control (NC) transfected in Kyse450 cells. (C) The expression ratio of the six transcription Factors in the MCTP1 three different regions siRNA versus the corresponding NC-transfected in Kyse450 cells.

Figure 6. The effects of the forced reversal of MCTP1 levels on the activity of the signaling pathways in Kyse450 versus Kyse510 cells. (A) The activity of the seventeen pathways in Kyse450 versus Kyse510 cells, and there is great difference among TGFβ, NFκB, MAPK/JNK cAMP/PKA, Hypoxia and IL-6 pathways. (B) The relative pathway activities of the three different regions’ si-MCTP1 versus the negative control (NC) transfected in Kyse450 cells. (C) The expression ratio of the six transcription Factors in the MCTP1 three different regions siRNA versus the corresponding NC-transfected in Kyse450 cells.