Research Paper Volume 12, Issue 24 pp 25658—25672

Up-regulation of circRNA-0003528 promotes mycobacterium tuberculosis associated macrophage polarization via down-regulating miR-224-5p, miR-324-5p and miR-488-5p and up-regulating CTLA4

Figure 6. The hsa_circ_0003528 signaling pathway was associated with M1 to M2 macrophage polarization (* P value < 0.05 vs. M(IL-4) group). (A) The expression of hsa_circ_0003528 between the M(IL-4) group and M(IFN-γ + LPS) group; (B) The expression of hsa_circ_0003528 between the M(M-CSF) group and M(GM-CSF) group; (C) The expression of hsa_circ_0003528 among the M(IFN-γ + LPS) group, M(IFN-γ + LPS) group and M(IL-4) group; (D) The expression of hsa_circ_0003528 among the M(IL-4) group, M(IL-4) group and M(IFN-γ + LPS) group. (E) The expression of miR-224-5p between the M(IL-4) group and M(IFN-γ + LPS) group; (F) The expression of miR-224-5p between the M(M-CSF) group and M(GM-CSF) group; (G) The expression of miR-224-5p among the M(IFN-γ + LPS) group, M(IFN-γ + LPS) group and M(IL-4) group; (H) The expression of miR-224-5p among the M(IL-4) group, M(IL-4) group and M(IFN-γ + LPS) group. (I) The expression of miR-324-5p between the M(IL-4) group and M(IFN-γ + LPS) group; (J) The expression of miR-324-5p between the M(M-CSF) group and M(GM-CSF) group; (K) The expression of miR-324-5p among the M(IFN-γ + LPS) group, M(IFN-γ + LPS) group and M(IL-4) group; (L) The expression of miR-324-5p among the M(IL-4) group, M(IL-4) group, and M(IFN-γ + LPS) group. (M) The expression of miR-488-5p between the M(IL-4) group and M(IFN-γ + LPS) group; (N) The expression of miR-488-5p between the M(M-CSF) group and M(GM-CSF) group; (O) The expression of miR-488-5p among the M(IFN-γ + LPS) group, M(IFN-γ + LPS) group, and M(IL-4) group; (P) The expression of miR-488-5p among the M(IL-4) group, M(IL-4) group, and M(IFN-γ + LPS) group. (Q) The expression of CTLA4 mRNA between the M(IL-4) group and M(IFN-γ + LPS) group; (R) The expression of CTLA4 mRNA between the M(M-CSF) group and M(GM-CSF) group; (S) The expression of CTLA4 mRNA among the M(IFN-γ + LPS) group, M(IFN-γ + LPS) group and M(IL-4) group; (T) The expression of CTLA4 mRNA among the M(IL-4) group, M(IL-4) group and M(IFN-γ + LPS) group.