Research Paper Volume 12, Issue 24 pp 25673—25683

Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b+Ly6G- myeloid cells

Figure 5. A cartoon illustrating the role of Atg7 in maintaining proper nucleosome assembly in bone marrow CD11b+Ly6G- myeloid cells. Deletion of Atg7 results in an increased percentage of the CD11b+Ly6G- cell population in the bone marrow of mice, accumulation of histone H3.1, cytoplasmic rather than nuclear localization, upregulation of genes related to nucleosome assembly, as well as upregulated aging markers in the CD11b+Ly6G- population, thereby suggesting a pivotal role of Atg7 in maintaining proper nucleosome assembly and limiting aging progression in the bone marrow CD11b+Ly6G- population.