Research Paper Volume 12, Issue 24 pp 25700—25717

Inhibition of PAR-1 delays aging via activating AMPK in C. elegans

Figure 3. par-1 mainly functions in the epidermis to regulate lifespan. (A) Survival curves of animals treated with the global control or par-1 RNAi (p < 0.0001, log-rank test). (B) Survival curves of animals treated with the germline plus intestine-enriched control or par-1 RNAi (p = 0.1756, log-rank test). (C) Survival curves of animals treated with the intestine-enriched control or par-1 RNAi (p = 0.6433, log-rank test). (D) Survival curves of animals treated with the muscle-enriched control or par-1 RNAi (p = 0.7955, log-rank test). (E) Survival curves of animals treated with the epidermis-enriched control or par-1 RNAi (p < 0.0001, log-rank test). In all cases, animals were treated with the control or par-1 RNAi during the adulthood. Detailed quantitative data and statistical analyses are included in Supplementary Table 1.