Research Paper Volume 12, Issue 24 pp 25730—25743

Cardamonin induces G2/M phase arrest and apoptosis through inhibition of NF-κB and mTOR pathways in ovarian cancer

Figure 3. Effects of cardamonin on cell cycle distribution of ovarian cancer cells. (A) Cells were treated with different concentrations of cardamonin for 48 h. Representative flow cytometry data on SKOV3 cells and PDC treated with cardamonin. Graphs showing changes in the percentage of cells at each phase of the cell cycle for both SKOV3 and PDC groups. (B) Representative western blots showing the effects of cardamonin on expression of cyclin D1, cyclin A, cyclin B1, p-cdc2, Myt1 and p-Histone H3. Data represent average results from three independent experiments; SD signifies standard deviation (n=3), **P<0.01 versus control group.