Research Paper Volume 12, Issue 24 pp 25730—25743

Cardamonin induces G2/M phase arrest and apoptosis through inhibition of NF-κB and mTOR pathways in ovarian cancer

Figure 8. Cardamonin inhibits tumor growth in vivo without serious side-effects. (A) Images showing tumors collected from each group. Tumor volumes and weights were measured every other day. (B) Graphs showing the changes of serum levels of ALT, AST, BUN and CREA levels in mouse. (C) Representative images showing the apoptosis detected in xenograft tumors with TUNEL assay. (D) IHC results showing the staining patterns of NF-κB and mTOR pathway-related proteins in tumors, **P<0.01, n=5.