Research Paper Volume 12, Issue 24 pp 25744—25766

Alisol B 23-acetate activates ABCG5/G8 in the jejunum via the LXRα/ACAT2 pathway to relieve atherosclerosis in ovariectomized ApoE-/- mice

Figure 4. AB23A reduces the ability of the proximal jejunum to metabolize exogenous lipids into the blood. (A) mRNA expression of targets related to lipid metabolism in the jejunum. (B, C) Western blot was used to detect the protein levels of LXRα, ABCG5, ABCG8 and ACAT2 in the proximal jejunum. (DG) Immunofluorescence detection of ABCG5 and ABCG8 in the proximal jejunum. p-values represent comparisons with the control group. The results represent the mean ± SEM (n=3/group).