Figure 5. The correlation between HLA and autophagy genes. (A) The difference in the transcriptome expression of each HLA gene between healthy and periodontitis samples. (B) The dot-plot demonstrated the correlations between each dysregulated HLA gene and each dysregulated autophagy gene. (C) The most positive correlated HLA-autophagy pair is EDEM1-HLA DOB and the expression is presented by violin-plot at the left panel, indicating there is a higher expression of EDEM1 and HLA-DOB in periodontitis. (D) The most negatively correlated HLA-autophagy pair is RAB11A-HLADOB and the expression status is presented by violin-plot at the right panel, indicating low expression of RAB11A and higher expression of HLA-DOB in periodontitis.