Research Paper Volume 13, Issue 1 pp 555—577

Autophagy-mediated regulation patterns contribute to the alterations of the immune microenvironment in periodontitis

The correlation between HLA and autophagy genes. (A) The difference in the transcriptome expression of each HLA gene between healthy and periodontitis samples. (B) The dot-plot demonstrated the correlations between each dysregulated HLA gene and each dysregulated autophagy gene. (C) The most positive correlated HLA-autophagy pair is EDEM1-HLA DOB and the expression is presented by violin-plot at the left panel, indicating there is a higher expression of EDEM1 and HLA-DOB in periodontitis. (D) The most negatively correlated HLA-autophagy pair is RAB11A-HLADOB and the expression status is presented by violin-plot at the right panel, indicating low expression of RAB11A and higher expression of HLA-DOB in periodontitis.

Figure 5. The correlation between HLA and autophagy genes. (A) The difference in the transcriptome expression of each HLA gene between healthy and periodontitis samples. (B) The dot-plot demonstrated the correlations between each dysregulated HLA gene and each dysregulated autophagy gene. (C) The most positive correlated HLA-autophagy pair is EDEM1-HLA DOB and the expression is presented by violin-plot at the left panel, indicating there is a higher expression of EDEM1 and HLA-DOB in periodontitis. (D) The most negatively correlated HLA-autophagy pair is RAB11A-HLADOB and the expression status is presented by violin-plot at the right panel, indicating low expression of RAB11A and higher expression of HLA-DOB in periodontitis.