Research Paper Volume 13, Issue 1 pp 578—597

Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans

Effect of IGF-I on the binding of DCN to IGF-IR. Aged-1 cells were serum-starved for 16 h, and then either treated with 200 ng/ml IGF-I (IGF-I) for 5 min or left untreated (U). Cells were harvested for co-immunoprecipitation assays and Western blot analyses for DCN and IGF-IR.

Figure 5. Effect of IGF-I on the binding of DCN to IGF-IR. Aged-1 cells were serum-starved for 16 h, and then either treated with 200 ng/ml IGF-I (IGF-I) for 5 min or left untreated (U). Cells were harvested for co-immunoprecipitation assays and Western blot analyses for DCN and IGF-IR.