Research Paper Volume 12, Issue 24 pp 25939—25955

Sexual dimorphism in aging hematopoiesis: an earlier decline of hematopoietic stem and progenitor cells in male than female mice

Figure 8. FSH and testosterone promote myeloid differentiation of middle-aged male and female LSK cells in vitro. (A and B) FSH at 0.2 and 1 μg/ml concentrations increased the number of CD45+Gr-1+ myeloid cells differentiated from LSK cells of middle-aged male and female mice. The percentage of CD45+Gr-1+ cells among total live cells is shown in (A) and the percentage of increase in CD45+Gr-1+ cells with FSH treatment is shown in (B). (C and D) Testosterone at 0.2 and 1 μg/ml concentrations increased the number of CD45+Gr-1+ myeloid cells differentiated from LSK cells of middle-aged male and female mice. The percentage of CD45+Gr-1+ cells among total live cells is shown in (C) and the percentage of increase in CD45+Gr-1+ cells with testosterone treatment is shown in (D).