Research Paper Volume 13, Issue 1 pp 598—618

EPHA5 mutations predict survival after immunotherapy in lung adenocarcinoma

Alterations in EPHA5 are associated with enhanced immunity in the TCGA LUAD cohort. (A) IFN-γ and chemokine signatures were enriched in EPHA5-Mut tumors. The ordinate log10value represents log10(ssGSEA score+1). (B) The expression levels of immune checkpoint inhibitor genes were significantly higher in EPHA5-Mut tumors than in EPHA5-WT tumors. The ordinate log10value represents log10(TPM+1). (C) A higher proportion of PDL1+/CD8+ cells was observed in EPHA5-Mut tumors than in EPHA5-WT tumors.

Figure 2. Alterations in EPHA5 are associated with enhanced immunity in the TCGA LUAD cohort. (A) IFN-γ and chemokine signatures were enriched in EPHA5-Mut tumors. The ordinate log10value represents log10(ssGSEA score+1). (B) The expression levels of immune checkpoint inhibitor genes were significantly higher in EPHA5-Mut tumors than in EPHA5-WT tumors. The ordinate log10value represents log10(TPM+1). (C) A higher proportion of PDL1+/CD8+ cells was observed in EPHA5-Mut tumors than in EPHA5-WT tumors.