Research Paper Volume 13, Issue 1 pp 598—618

EPHA5 mutations predict survival after immunotherapy in lung adenocarcinoma

Knockdown of EPHA5 in H1299 cells impaired immune related pathways enrichment and expression of immune checkpoint genes. EPHA5 depletion in H1299 cells reduced the enrichment of (A) IFN-γ, (B) TNF, and (C) NF-κB signaling pathway components. (D) EPHA5 KD in H1299 cells downregulated the expression of PDL1 (CD274), IDO1 and CXCL10. **: P P

Figure 3. Knockdown of EPHA5 in H1299 cells impaired immune related pathways enrichment and expression of immune checkpoint genes. EPHA5 depletion in H1299 cells reduced the enrichment of (A) IFN-γ, (B) TNF, and (C) NF-κB signaling pathway components. (D) EPHA5 KD in H1299 cells downregulated the expression of PDL1 (CD274), IDO1 and CXCL10. **: P < 0.01, ***: P < 0.001.