Figure 4. EPHA5 mutations are related to increased TMB and TNB in LUAD. EPHA5-Mut tumors had a markedly higher TMB than EPHA5-WT tumors in both the (A) TCGA LUAD cohort and (B) MSKCC immunotherapy LUAD cohort. The ordinate log10value represents log10(TMB+1). (C) In the TCGA LUAD cohort, EPHA5-Mut tumors had an increased immunogenic TNB. The ordinate log10value representslog10(TNB+1). (D) EPHA5 mutations were positively correlated with enrichment of the cell cycle and DNA replication pathways in the TCGA LUAD cohort. (E) Significantly increased mutation frequencies of genes in the HR and MMR pathways were observed in EPHA5-Mut tumors in the TCGA LUAD cohort.