Research Paper Volume 13, Issue 1 pp 619—645

A three-gene signature based on tumour microenvironment predicts overall survival of osteosarcoma in adolescents and young adults

The differences of genes expression and pathways enrichment based on immune scores and stromal scores. (A, B) Heatmap of significantly differentially expressed genes based on immune and stromal scores. (C, D) Venn diagram analysis of aberrantly expressed genes based on immune and stromal scores in osteosarcoma. (E) GO analyses of the tmDEGs in the categories of biological processes (BP), cellular components (CC), and molecular functions (MF). (F) KEGG analysis of tmDEGs genes. tmDEGs, differentially expressed genes of the tumour microenvironment. GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.

Figure 3. The differences of genes expression and pathways enrichment based on immune scores and stromal scores. (A, B) Heatmap of significantly differentially expressed genes based on immune and stromal scores. (C, D) Venn diagram analysis of aberrantly expressed genes based on immune and stromal scores in osteosarcoma. (E) GO analyses of the tmDEGs in the categories of biological processes (BP), cellular components (CC), and molecular functions (MF). (F) KEGG analysis of tmDEGs genes. tmDEGs, differentially expressed genes of the tumour microenvironment. GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.