Research Paper Volume 13, Issue 1 pp 646—674

MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role


Figure 5. Reversal association and correlation of MITF in clinical significance. Kaplan-Meier survival estimated the association of MITF expression and survival of patients with skin cutaneous melanoma (SKCM) (A) or with lung adenocarcinoma (LUAD) (B) in TCGA database. The correlation of MITF and ANXA1 expression in skin cutaneous melanoma (n = 363) (C) or in lung adenocarcinoma (n = 507) (D). The TCGA PanCancer Atlas database was analyzed by cBioPortal. (E) The mRNA log2 T/N ratio of indicated genes of 89 lung adenocarcinoma patients from Taiwanese cohort and the Spearman’s correlation with MITF. q < 0.05 was considered statistically significant.