Research Paper Volume 13, Issue 1 pp 646—674

MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role

The illustration of the role of MITF in lung adenocarcinoma and melanoma. We hypothesize that the different MITF isoforms and their transcriptional regulations lead to opposite impacts on cancer progression. The dominant isoform MITF-A expresses in CL1-0 cells and inhibits cell invasion by repressing FZD7 expression. Additionally, MITF activates ANXA1, VEGFC, PDGFC and LRRN3 in lung adenocarcinoma, but suppresses ANXA1, VEGFC, PDGFC and LRRN3 in melanoma. The red lines indicate the “activate” and the green lines indicate the “repress”.

Figure 6. The illustration of the role of MITF in lung adenocarcinoma and melanoma. We hypothesize that the different MITF isoforms and their transcriptional regulations lead to opposite impacts on cancer progression. The dominant isoform MITF-A expresses in CL1-0 cells and inhibits cell invasion by repressing FZD7 expression. Additionally, MITF activates ANXA1, VEGFC, PDGFC and LRRN3 in lung adenocarcinoma, but suppresses ANXA1, VEGFC, PDGFC and LRRN3 in melanoma. The red lines indicate the “activate” and the green lines indicate the “repress”.