Research Paper Volume 13, Issue 1 pp 735—749

TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway

TRIM3 relieved oxidative stress in PD cell model. (A and B) TRIM3 mRNA and protein expression in SH-SY5Y cells was successfully regulated by transfection. (C) TRIM3 significantly elevated the level of GSH and SOD in SH-SY5Y cells induced by MPP+ solution. (D) TRIM3 markedly reduced the level of ROS in SH-SY5Y cells induced by MPP+ solution. (E) TRIM3 prominently decreased the MMP in SH-SY5Y cells induced by MPP+ solution. * P P

Figure 3. TRIM3 relieved oxidative stress in PD cell model. (A and B) TRIM3 mRNA and protein expression in SH-SY5Y cells was successfully regulated by transfection. (C) TRIM3 significantly elevated the level of GSH and SOD in SH-SY5Y cells induced by MPP+ solution. (D) TRIM3 markedly reduced the level of ROS in SH-SY5Y cells induced by MPP+ solution. (E) TRIM3 prominently decreased the MMP in SH-SY5Y cells induced by MPP+ solution. * P < 0.05 and ** P < 0.01.