Research Paper Volume 13, Issue 1 pp 750—768

KRAS mutations are negatively correlated with immunity in colon cancer

Six immune pathways were enriched with KRAS mutations. As shown in the enrichment plots, KRAS mutations were positively correlated with the immune pathways: macrophage M1 and M2, NK cell differentiation, class I MHC-mediated antigen processing, B cell receptor signaling, IL-2 and IL-17 pathways.

Figure 3. Six immune pathways were enriched with KRAS mutations. As shown in the enrichment plots, KRAS mutations were positively correlated with the immune pathways: macrophage M1 and M2, NK cell differentiation, class I MHC-mediated antigen processing, B cell receptor signaling, IL-2 and IL-17 pathways.