Research Paper Volume 13, Issue 1 pp 769—781

The microRNA miR-29c-5p inhibits cell proliferation and migration by targeting TMEM98 in head and neck carcinoma

TMEM98 overexpression reverses the tumor suppressor effects of miR-29c-5p. (A, B) TMEM98 expression in FaDu and HSC-3 cells transfected with miR-29c-5p mimics, miR-29c-5p mimics combined with the TMEM98-overexpression plasmid, or control. (C, D) Cell proliferation was significantly lower in cells with upregulated miR-29c-5p expression, while cell numbers were restored to those of the control. (E, F) Cell cycle analysis of HNSCC cells transfected with miR-29c-5p mimics, miR-29c-5p mimics combined with the TMEM98-overexpression plasmid, or control. (G, H) Cell migration was significantly decreased in cells transfected with the miR-29c-5p mimic and increased after upregulation of TMEM98 expression. *p

Figure 6. TMEM98 overexpression reverses the tumor suppressor effects of miR-29c-5p. (A, B) TMEM98 expression in FaDu and HSC-3 cells transfected with miR-29c-5p mimics, miR-29c-5p mimics combined with the TMEM98-overexpression plasmid, or control. (C, D) Cell proliferation was significantly lower in cells with upregulated miR-29c-5p expression, while cell numbers were restored to those of the control. (E, F) Cell cycle analysis of HNSCC cells transfected with miR-29c-5p mimics, miR-29c-5p mimics combined with the TMEM98-overexpression plasmid, or control. (G, H) Cell migration was significantly decreased in cells transfected with the miR-29c-5p mimic and increased after upregulation of TMEM98 expression. *p < 0.05, **p < 0.01, ***p < 0.001.