Research Paper Volume 13, Issue 1 pp 831—845

Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice

Changes in the expression of LC3 and α-syn Ser129 in MPTP mice. The expression of LC3 in the substantia nigra neurons of C57BL/6 mice (A–D). The expression of α-Syn Ser129 in the substantia nigra neurons of C57BL/6 mice (E–H). Bar = 20 μm. Quantitative analysis of LC3 and α-Syn average optical (I, J). The results are expressed as ***p #p

Figure 4. Changes in the expression of LC3 and α-syn Ser129 in MPTP mice. The expression of LC3 in the substantia nigra neurons of C57BL/6 mice (AD). The expression of α-Syn Ser129 in the substantia nigra neurons of C57BL/6 mice (EH). Bar = 20 μm. Quantitative analysis of LC3 and α-Syn average optical (I, J). The results are expressed as ***p < 0.001 compared to atorvastatin/MPTP (-/-). The results were expressed as #p < 0.05 compared to atorvastatin/MPTP (-/+).