Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice
The α-syn Ser129, LC3 and CYBB/NOX2 changed in the MPTP-induced autophagic flux mice (A–D). The western blot results show the protein expression of NOX2 (B), α-Syn Ser129 (C) and LC3-II/LC3-I (D) in the substantia nigra neurons of autophagic flux mice. The results compared to atorvastatin/MPTP (-/-) are expressed as *p < 0.05, **p < 0.01, ***p < 0.001. The results/MPTP (-/+) were expressed as ##p < 0.01 or ###p < 0.001 compared to atorvastatin.