Research Paper Volume 13, Issue 1 pp 831—845

Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice

Inhibition of NOX2 increases the protein level of LC3 and decreases α-Syn Ser129 in MPTP-lesioned mCherry-eGFP-tagged mice (A–D). The western blot results showed the protein expression of NOX2 (B), α-Syn Ser129 (C) and LC3-II/LC3-I (D) in the substantia nigra neurons of C57BL/6 mice. The results are expressed as *p **p #p ###p

Figure 7. Inhibition of NOX2 increases the protein level of LC3 and decreases α-Syn Ser129 in MPTP-lesioned mCherry-eGFP-tagged mice (AD). The western blot results showed the protein expression of NOX2 (B), α-Syn Ser129 (C) and LC3-II/LC3-I (D) in the substantia nigra neurons of C57BL/6 mice. The results are expressed as *p < 0.05 or **p < 0.01 compared to NOX2-shRNA/MPTP (-/-). The results were expressed as #p < 0.05 or ###p < 0.001 compared to NOX2-shRNA/MPTP (-/+).