Research Paper Volume 13, Issue 1 pp 831—845

Atorvastatin improves motor function, anxiety and depression by NOX2-mediated autophagy and oxidative stress in MPTP-lesioned mice

The effect of NOX2 inhibition on autophagic flux. The expression of eGFP-LC3 in the substantia nigra neurons of the marker mouse model (A–D). The expression of mCherry-LC3 in the substantia nigra neurons of the autophagic flux marker mouse model (E–H). The merged figures show the expression of eGFP-mCherry-LC3 (I–L). Bar = 20 μm. Quantitative analysis of eGFP, mCherry and merged positive area (M). The results are expressed as ***p p

Figure 8. The effect of NOX2 inhibition on autophagic flux. The expression of eGFP-LC3 in the substantia nigra neurons of the marker mouse model (AD). The expression of mCherry-LC3 in the substantia nigra neurons of the autophagic flux marker mouse model (EH). The merged figures show the expression of eGFP-mCherry-LC3 (IL). Bar = 20 μm. Quantitative analysis of eGFP, mCherry and merged positive area (M). The results are expressed as ***p < 0.001 compared to atorvastatin/MPTP (-/-). The results were expressed as **p < 0.01 compared to atorvastatin/MPTP (-/+).