Research Paper Volume 13, Issue 1 pp 865—876

Propofol reduces renal ischemia/reperfusion-induced acute lung injury by stimulating sirtuin 1 and inhibiting pyroptosis

Propofol ameliorates the morphological characteristics of rI/R-induced ALI in rats. Rats were subjected to rI/R, with or without propofol (5 or 10 mg/kg) treatment for 24 h. (A) H&E analysis was performed, and the lung injury score was determined. (B) Immunohistochemistry was used to measure the fluorescence intensity of myeloperoxidase. (C) Immunofluorescence analysis was used to measure the fluorescence intensity of F4/80. (D) TUNEL analysis was used to measure the apoptotic index (%) (*P #P

Figure 4. Propofol ameliorates the morphological characteristics of rI/R-induced ALI in rats. Rats were subjected to rI/R, with or without propofol (5 or 10 mg/kg) treatment for 24 h. (A) H&E analysis was performed, and the lung injury score was determined. (B) Immunohistochemistry was used to measure the fluorescence intensity of myeloperoxidase. (C) Immunofluorescence analysis was used to measure the fluorescence intensity of F4/80. (D) TUNEL analysis was used to measure the apoptotic index (%) (*P < 0.05 vs. sham; #P < 0.05 vs. rI/R).