Research Paper Volume 13, Issue 1 pp 877—893

Coicis semen protects against focal cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting angiogenesis via the TGFβ/ALK1/Smad1/5 signaling pathway

Coicis semen treatment reduced the infarct volume, improved neurological function and decreased the brain water content in MCAO mice. (A) TTC staining of brain sections from vehicle- or Coicis Semen-treated mice taken at 3 days poststroke. (B, C, D) Effects of Coicis Semen at different concentration on infarct volume, neurological score and brain water content in mice at 3 days poststroke. Mean ± SD. n = 5. aP bP

Figure 1. Coicis semen treatment reduced the infarct volume, improved neurological function and decreased the brain water content in MCAO mice. (A) TTC staining of brain sections from vehicle- or Coicis Semen-treated mice taken at 3 days poststroke. (B, C, D) Effects of Coicis Semen at different concentration on infarct volume, neurological score and brain water content in mice at 3 days poststroke. Mean ± SD. n = 5. aP < 0.05 vs. vehicle; bP < 0.05 vs. Coicis Semen (50 mg/kg). Statistical analyses were performed by one-way ANOVA followed by Tukey’s multiple comparison tests.