Research Paper Volume 13, Issue 1 pp 877—893

Coicis semen protects against focal cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting angiogenesis via the TGFβ/ALK1/Smad1/5 signaling pathway

Coicis semen treatment promoted long-term neurological recovery after ischemic stroke. (A) The ipsilateral infarct volume was detected at 3, 7 and 14 days after stroke by using TTC staining and then normalized to the infarct volume of the contralateral hemisphere to correct for edema; the data are expressed as a percentage. (B) Bar graphs show quantified infarct volumes. n =5, aP t-test. (C) Neurological deficit scores. n =5. (D) Survival rate. n = 15-20 (E) Pole test time. (F) Beam walking time. Mean ± SD. n = 10-12. aP

Figure 2. Coicis semen treatment promoted long-term neurological recovery after ischemic stroke. (A) The ipsilateral infarct volume was detected at 3, 7 and 14 days after stroke by using TTC staining and then normalized to the infarct volume of the contralateral hemisphere to correct for edema; the data are expressed as a percentage. (B) Bar graphs show quantified infarct volumes. n =5, aP < 0.05 vs. vehicle. Statistical analyses were performed by two-tailed Student’s t-test. (C) Neurological deficit scores. n =5. (D) Survival rate. n = 15-20 (E) Pole test time. (F) Beam walking time. Mean ± SD. n = 10-12. aP < 0.05 vs. vehicle by one-way ANOVA followed by Tukey’s multiple comparison tests (individual time points).