Research Paper Volume 13, Issue 1 pp 877—893

Coicis semen protects against focal cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting angiogenesis via the TGFβ/ALK1/Smad1/5 signaling pathway

Coicis semen treatment reduced oxidative stress levels after ischemic stroke. (A) Changes in the production of ROS were revealed by DHE staining. Scale bar =50 μm. (B) Quantification of ROS-positive cells in the brain. n = 5, aP t-test. (C, D, E) The levels of GSH, MDA and SOD were quantified by using commercial kits. Mean ± SD. n = 5. aP t-test.

Figure 3. Coicis semen treatment reduced oxidative stress levels after ischemic stroke. (A) Changes in the production of ROS were revealed by DHE staining. Scale bar =50 μm. (B) Quantification of ROS-positive cells in the brain. n = 5, aP < 0.05 vs. vehicle. Statistical analyses were performed by two-tailed Student’s t-test. (C, D, E) The levels of GSH, MDA and SOD were quantified by using commercial kits. Mean ± SD. n = 5. aP < 0.05 vs. vehicle. Statistical analyses were performed by two-tailed Student’s t-test.