Research Paper Volume 13, Issue 1 pp 894—909

The emerging role of the MiR-1272-ADAM9-CDCP1 signaling pathway in the progression of glioma


Figure 4. Ectopic expression of ADAM9 abolishes miR-1272-induced anti-tumor effects on glioma cell behaviors. (A) ADAM9 re-shaped the glioma cell cycle distribution induced by miR-1272, as assessed with flow cytometry. (B) Statistical diagram of the cell cycle results. Statistical results of G1 phase were marked with asterisks. (C) Restoration of ADAM9 reversed miR-1272-induced effects on cell proliferation in glioma cells, as assessed by proliferation assay. (D) ADAM9 abolished miR-1272-induced inhibition of cell migration, as assessed by Transwell assay. (E) Statistical diagram of the migration results. Error bars represent mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001.