Research Paper Volume 12, Issue 24 pp 25981—25999

Profilin 2 promotes growth, metastasis, and angiogenesis of small cell lung cancer through cancer-derived exosomes

Figure 4. Exosome derived from SCLC showing influence on H446 cells. OE-exo promoted the proliferation (P=0.000) (A), migration (P=0.0002) (B), invasion (P=0.0019) (C) of H446 cells. Conversely, KD-exo inhibited proliferation (p=0.000) (D), migration (p=0.0051) (E), invasion (P=0.03) (F) of H446 cells. Exosomes from H446-OC, H446-KC, and H446-WT have similar function in promoting the proliferation (P=0.5288, 0.0076, 0.000 and 0.0014 at 6 h, 12 h, 18 h, and 24 h, respectively) (G), migration (P=0.0350) (H), and invasion (P=0.0231) (I) of H446 cells, which could significantly promote the proliferation, migration and invasion of H446 cells compared with that of control cells non-treated with exosomes (no-exo).