Figure 8. PFN2 promotes tumor growth and metastasis in-vivo. The size and weight of tumor in the H446-OE group is significantly higher than those of tumor in the H446-OC group in xenograft mice model (A–C). There is a significantly higher number of blood vessels in tumor in the H446-OE group than in that in the H446-OC group; meanwhile, Smad3 expression is higher in the H446-OE group than in H446-OC group (D). H446-OE cells could remarkably promote metastasis in vivo (E), confirmed by hematoxylin and eosin staining (F); the number of Ki67 positive cell in metastatic tumor in the lung is significantly higher than that in the adjacent tissues (F).