Research Paper Volume 13, Issue 3 pp 3368—3385

Amorphous nano-selenium quantum dots prevent pulmonary arterial hypertension through recoupling endothelial nitric oxide synthase

Administration of A-SeQDs is more effective to prevent monocrotaline-induced PAH than C-SeQDs and selenium supplementation in mice. The experimental protocol was shown in Supplementary Figure 3A. C57B16 mice were given selenium supplementation, C-SeQDs, A-SeQDs in regular diet one week prior to a single intraperitoneal injection of 100 mg/kg monocrotaline or vehicle. Three weeks after injection, mean pulmonary arterial pressure (PAP) in (A), right ventricle systolic pressure (RVSP) in (B), and mean blood pressure (mBP) in (C) were measured by radio telemetry. All data were expressed as mean ± SEM. 10-15 mice were in each group. *PVS Vehicle alone, #P VS monocrotaline alone. &PVS monocrotaline plus Selenium or C-SeQDs. A one-way ANOVA followed by Tukey post-hoc tests was used to produce the P values.

Figure 2. Administration of A-SeQDs is more effective to prevent monocrotaline-induced PAH than C-SeQDs and selenium supplementation in mice. The experimental protocol was shown in Supplementary Figure 3A. C57B16 mice were given selenium supplementation, C-SeQDs, A-SeQDs in regular diet one week prior to a single intraperitoneal injection of 100 mg/kg monocrotaline or vehicle. Three weeks after injection, mean pulmonary arterial pressure (PAP) in (A), right ventricle systolic pressure (RVSP) in (B), and mean blood pressure (mBP) in (C) were measured by radio telemetry. All data were expressed as mean ± SEM. 10-15 mice were in each group. *P<0.05 VS Vehicle alone, #P < 0.05 VS monocrotaline alone. &P<0.05 VS monocrotaline plus Selenium or C-SeQDs. A one-way ANOVA followed by Tukey post-hoc tests was used to produce the P values.