Research Paper Volume 13, Issue 1 pp 973—990

Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy

The analysis of protein-protein interactions. (A) The protein-protein interactions network of the top 20 differentially expressed proteins in the closest connection. (B) The protein-protein interactions network of the differentially expressed proteins enriched in autophagy and apoptosis pathways. The green circles refer to the differentially expressed proteins enriched in autophagy pathway, the purple circles represent the proteins enriched in apoptosis pathway, and the pink circles the both.

Figure 3. The analysis of protein-protein interactions. (A) The protein-protein interactions network of the top 20 differentially expressed proteins in the closest connection. (B) The protein-protein interactions network of the differentially expressed proteins enriched in autophagy and apoptosis pathways. The green circles refer to the differentially expressed proteins enriched in autophagy pathway, the purple circles represent the proteins enriched in apoptosis pathway, and the pink circles the both.