Research Paper Volume 13, Issue 1 pp 973—990

Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy

The expression of CTSB, CTSD, and CTSL in vitreous, serum, and blood cells of patient cohorts. (A–C) The protein levels of CTSB, CTSD, and CTSL in vitreous humor of the patients with RRD and PDR. n = 35 – 39 / group. (D–F) The protein levels of CTSB, CTSD, and CTSL in serum of the patients with RRD and PDR. n = 35 – 39 / group. (G–I) The relative expression levels of CTSB, CTSD, and CTSL genes in blood cells of an extra patient cohort. n = 12 / group. Data are expressed as mean ± SEM. * P P P

Figure 4. The expression of CTSB, CTSD, and CTSL in vitreous, serum, and blood cells of patient cohorts. (AC) The protein levels of CTSB, CTSD, and CTSL in vitreous humor of the patients with RRD and PDR. n = 35 – 39 / group. (DF) The protein levels of CTSB, CTSD, and CTSL in serum of the patients with RRD and PDR. n = 35 – 39 / group. (GI) The relative expression levels of CTSB, CTSD, and CTSL genes in blood cells of an extra patient cohort. n = 12 / group. Data are expressed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001.