Research Paper Volume 13, Issue 1 pp 1153—1175

Construction of an mRNA-miRNA-lncRNA network prognostic for triple-negative breast cancer

Screening of key genes in TNBC. Key genes were identified from the top 10 hub genes of the significant dysregulated DE-mRNAs by merging the prognosis and expression analyses using Kaplan Meier-plotter and GEPIA databases. Expression boxplots and survival curves (overall survival [OS]) of 12 key genes, including 10 upregulated hub genes (CDK1, CCNB1, CCNA2, CDC20, TOP2A, CCNB2, MAD2L1, BUB1, KIF11, and RRM2) and two downregulated hub genes (ESR1 and IGF1) in TNBC are presented.

Figure 4. Screening of key genes in TNBC. Key genes were identified from the top 10 hub genes of the significant dysregulated DE-mRNAs by merging the prognosis and expression analyses using Kaplan Meier-plotter and GEPIA databases. Expression boxplots and survival curves (overall survival [OS]) of 12 key genes, including 10 upregulated hub genes (CDK1, CCNB1, CCNA2, CDC20, TOP2A, CCNB2, MAD2L1, BUB1, KIF11, and RRM2) and two downregulated hub genes (ESR1 and IGF1) in TNBC are presented.