Research Paper Volume 13, Issue 1 pp 1212—1235

Therapeutic potential of targeting HSPA5 through dual regulation of two candidate prognostic biomarkers ANXA1 and PSAT1 in osteosarcoma

The potential association between ANXA1 and HSPA5. (A) Genes involved in magenta module shown in scatter plot. Cut-off of module membership = 0.8 and gene significances for survival time = 0.2 as the criteria for the hub genes where ANXA1 included. (B) Gene ontology analysis of genes linked to ANXA1 expression based on the topological overlap. (C) The positive correlation between ANXA1 and HSPA5 mRNA expression levels (log2) in TARGET

Figure 5. The potential association between ANXA1 and HSPA5. (A) Genes involved in magenta module shown in scatter plot. Cut-off of module membership = 0.8 and gene significances for survival time = 0.2 as the criteria for the hub genes where ANXA1 included. (B) Gene ontology analysis of genes linked to ANXA1 expression based on the topological overlap. (C) The positive correlation between ANXA1 and HSPA5 mRNA expression levels (log2) in TARGET_OS dataset. Statistical P-value was obtained by Pearson correlation analysis. (D) ANXA1 and HSPA5 expression levels in bone marrow cancer and normal tissues through GENT2 online analysis.