Research Paper Volume 12, Issue 24 pp 24651—24670

Downregulated genes by silencing MYC pathway identified with RNA-SEQ analysis as potential prognostic biomarkers in gastric adenocarcinoma

Figure 1. Effect of MYC silencing on gene and protein expression in ACP02 and ACP03. The heat maps with hierarchical grouping show how the levels of gene and protein expression of TTLL12, CDKN3, CDC16, PTPRA, MZT2B, UBE2T are related to MYC in the ACP02 (A) and (B) and ACP03 (C) and (D). All comparisons were made concerning non-neoplastic gastric mucosa MNP01. Z-score was the metric applied to test the clustering between genes. Blue gradients represent a lower Z-score (genes with a lower level of expression) and red gradients represent a higher Z-score (genes with a higher level of expression).