Research Paper Volume 13, Issue 1 pp 1236—1250

High-fat diet induced discrepant peripheral and central nervous systems insulin resistance in APPswe/PS1dE9 and wild-type C57BL/6J mice

Glucose tolerance, serum parameter levels and liver histological changes in C57 WT and APP/PS1 mice treated with different diets. Glucose tolerance test was performed after HFD intervention for 3 (A) or 6.5 months (B) respectively. Fasting blood glucose, insulin levels (C), serum lipid parameters levels (D) and inflammatory factor levels (E) were measured at the end of experiment. Values presented as the mean ± SE, n = 10 for each group. a: comparing with C57 CON group, P P P F) were detected by using HE staining method. (a) control diet-treated C57 WT mice; (b) 60% HFD-treated C57 WT mice; (c) control diet-treated APP/PS1 mice; (d) 60% HFD-treated APP/PS1 mice. Scale bar: 20μm.

Figure 2. Glucose tolerance, serum parameter levels and liver histological changes in C57 WT and APP/PS1 mice treated with different diets. Glucose tolerance test was performed after HFD intervention for 3 (A) or 6.5 months (B) respectively. Fasting blood glucose, insulin levels (C), serum lipid parameters levels (D) and inflammatory factor levels (E) were measured at the end of experiment. Values presented as the mean ± SE, n = 10 for each group. a: comparing with C57 CON group, P < 0.05; b: comparing with C57 60% HFD group, P < 0.05; c: comparing with APP/PS1 CON group, P < 0.05. Liver histological changes (F) were detected by using HE staining method. (a) control diet-treated C57 WT mice; (b) 60% HFD-treated C57 WT mice; (c) control diet-treated APP/PS1 mice; (d) 60% HFD-treated APP/PS1 mice. Scale bar: 20μm.